| Original document(112 pages) 中文版 |
Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided. |
Application Number
申请号 |
200480023040 |
Application Date
申请日 |
2004.06.11 |
| Title 名称 |
Peptides enhancing CEH activity or ACAT inhibitory activity, pharmaceutical compositions comrising these peptides and their use in the treatment of atherosclerosis
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Publication Number
公开号 |
1835970 |
Publication Date
公开日 |
2006.09.20 |
| Approval Pub. Date |
|
Granted Pub. Date |
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| International Classification 分类号 |
C07K14/47,C07K7/08,A61K38/10,A61K38/17,A61K47/48 |
Applicant(s) Name
申请人 |
Univ Kingston |
| Address 地址 |
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| Inventor(s) Name 发明人 |
Kisilevsky Robert, Tam Shui-pang, Ancsin John B. |
| Attorney & Agent 代理人 |
guo xiaodong |
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