| Original document(82 pages) 中文版 |
The present invention relates to tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. More precisely, the present invention relates to tricyclic derivatives as colchicine derivatives, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. Tricyclic derivatives of the present invention show very powerful cytotoxici ty to cancer cell lines but were much less toxic than colchicine or taxol, confirmed through animal toxicity test. Tricyclic derivatives of the inventi on also decrease the volume and weight of a tumor and have a strong angiogenesi s inhibiting activity in HUVEC cells. Thus, tricyclic derivatives of the prese nt invention can effectively be used as an anticancer agent, anti-proliferation agent and an angiogenesis inhibitor. |
Application Number
申请号 |
200480021267 |
Application Date
申请日 |
2004.06.23 |
| Title 名称 |
Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them
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Publication Number
公开号 |
1826316 |
Publication Date
公开日 |
2006.08.30 |
| Approval Pub. Date |
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Granted Pub. Date |
|
| International Classification 分类号 |
C07C317/30 |
Applicant(s) Name
申请人 |
Je Il Pharmaceutical Co., Ltd. |
| Address 地址 |
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| Inventor(s) Name 发明人 |
Choi Jae-won, Kim Kwang Hee, Choi Jong-hee, Park Sang-woo, Chun Kwangwoo, Oh Byung-kyu, Joe Bo-young |
| Attorney & Agent 代理人 |
zhao rongmin lu xiaolong |
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