| Original document(41 pages) 中文版 |
The invention provides the 2-substituent acylamino dicarboxilic acid compound with the general formula (I) in right or salt accepected in pharmacy, which possesses high combined activity (KD=0.20M) with PPAR protein ligand structure, reduces the interaction of PPAR and RXR, inhibits the activity of Luogelie ketone (IC50-8.67M) in the yeast dual crossing system effectively, the inhibited activity of Luogelie ketone in the mammalian trans-activating experiment is IC50=31.9 M. The compound displays high patent medicine value. The invention also provides the compound preparing method and pharmaceutical composition. |
Application Number
申请号 |
200410093185 |
Application Date
申请日 |
2004.12.17 |
| Title 名称 |
2-substituted amido dicarboxylic acid, its preparation method and use
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Publication Number
公开号 |
1789240 |
Publication Date
公开日 |
2006.06.21 |
| Approval Pub. Date |
|
Granted Pub. Date |
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| International Classification 分类号 |
C07C237/12,C07C231/10,C07C217/06,C07D209/14,A61K31/195,A61K31/404,A61P3/10,A61P3/04 |
Applicant(s) Name
申请人 |
Shanghai Institute of Materia Medica CAS |
| Address 地址 |
201203 |
| Inventor(s) Name 发明人 |
Shen Xu, Jiang Hualiang, Shen Jianhua, Ye Fei, Deng Guanghui, Liu Hong, Luo Xiaomin |
| Attorney & Agent 代理人 |
zhang ping fei kaikui |
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