Original document(41 pages)  中文版
    Compounds of formula (I): wherein R is hydrogen, C1-10alkyl, C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, phenylC1-6alkyl or phenyl; R<1> is C1-6alkyl, C2-6alkenyl, C1-6alkoxy, halo, hydroxy, C1-6alkanoyl, haloC1-6alkyl, cyano or nitro; m is 0, 1 or 2; R<2> is C1-6alkyl; n is 0, 1 or 2; are empomil inhibitors and are useful in the treatment of neurological disorders such as stroke, head trauma, transient cerebral ischemic attack, and chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, diabetic neuropathy, amyotrophic lateral sclerosis, multiple sclerosis, vascular dementia and AIDS-related dementia.
Application Number
98812282 Application Date
Title 名称 1,4-diazacycloheptane derivatives
Publication Number
1282322 Publication Date
Approval Pub. Date Granted Pub. Date
International Classification 分类号 A61K31/55;C07D243/08
Applicant(s) Name
Astra Zeneca Ltd.
Address 地址
Inventor(s) Name 发明人 R.A. Keith;E.J. Warawa;T.R. Simpson
Attorney & Agent 代理人 zhang yuanzhong

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