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Molecular formula :
CAS :
nature : the virus from the S gene encodes a protein Main (S), protein (MS) and the protein (LS) three forms, they have a common C - , but the translation initiation site and the various different amino terminal. The main protein (S) from 226 amino acid composition; Protein (MS) in front of the main protein of more than 55 amino acid sequence of pre S2; Large protein (LS) in the protein before another 108 or 119 amino acids (depending on the different subtypes) of the pre-S1 sequence, it was part of the (LS and S) or full (MS) glycosylation, glycosylation and non-glycosylation two forms. S is the virus coat protein and 22mm surface antigen particles of the major components, total protein accounted for 80% ~ 90% have a very strong immune (but non-glycosylation of immunogenicity only glycosylation 0.13). Past HBV carriers from the Division serum antigen on the surface of particles as antigen, used for the preparation of vaccines. 1986 engineered vaccine production in the market, known as the second-generation vaccine. Now used in the production of hepatitis B vaccine host a yeast and mammalian cells, recombinant vaccinia virus and insect baculovirus system (baculo-virus) system. Later, it was found protein (MS) and the protein (LS) is different from the main protein (S) immune determinant, with the pre S hepatitis B vaccine may have stronger immune. Especially large protein (LS), is noteworthy immunogen.
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