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Drug Name: propranolol hydrochloride sustained-release tablets
English: Propranolol Hydrochloride Sustained Release Tablets
Chinese pinyin : Yansuan Punailuo'er Huanshipian
main components: hydrochloride Puluoer
traits: white tablets.
pharmacological effects: β - adrenergic receptor blockers, beta receptor blocking myocardial slowed heart rate, cardiac contractility and inhibition atrioventricular conduction, cardiac output and blood flow to reduce cycle, reducing myocardial oxygen consumption ; reduce the renin and aldosterone secretion, decreased vascular tone, acute toxicity test results: Mouse oral LD50 638.19mg/kg.
Pharmacokinetics: a meeting on the 1st oral, gastrointestinal tract slow release, steady state plasma peak time of 5.5 hours, peak plasma concentration 79.7mg/ml (80mg dose / th ), the half-life of 7.0 hours. Drugs in a strong first pass liver effects, through the blood-brain barrier and the placental protein binding rate greater than 90%. Drug metabolism in the liver, kidney excretion of metabolites from.
indications: used to control hypertension and angina treatment, can also be used for acute myocardial infarction after more long-term prevention.
usage and consumption: oral. A meeting on the 1st.
Adults:
hypertension: 40mg day, taking in the morning or the evening, after taking the majority of patients have some effect. When necessary, will be increased to 80mg. Again, as in taking diuretics or other service antihypertensive drugs, blood pressure can be further reduced.
angina: taking 40mg a day, often received effect, the patient convenience, in the morning or evening use.
more after myocardial infarction: myocardial infarction should be 5 to 21 days after the start of oral propranolol hydrochloride tablets, 40mg a day four times, serving two days or three days later, a day of the oral 160mg. Compliance is extremely important, because of the need to maintain long-term β - antagonistic effect.
children: Not recommended children.
adverse reaction: greater tolerance in general, such as acromegaly cold (cold extremities), nausea, diarrhea, sleep disorder and burnout, mild reaction is often short, there have been a small number of patients had a low platelet count reduce and Purpura.
had reported: the use of beta-adrenergic receptor antagonist, a rash and dry eyes (dry eye). These cases rarely reported, after stopping most of these symptoms will disappear. If
of taboos: following Prohibited:
two and three in a cardiac conduction block (heart block).
two cardiogenic shock patients.
three have a history of bronchial spasm patients.
four long fasting patients.
five metabolic acidosis (for example: some diabetes patients).
six severe heart failure.
seven sinus bradycardia.
Note: heart of a small reserve to pay special attention to the patient, obviously heart failure should avoid the use of beta-adrenergic receptor antagonist drugs, but may have been used to control symptoms of failure patients.
separate use of thyrotoxicosis caused by heart failure is often effective, but accompanied by other symptoms (adverse fac-tors), to be used digitalis drugs and diuretics to maintain myocardial contractility and control failure symptoms.
one of the pharmacological effect is to reduce the heart rate, bradycardia (usually less than 50 to 55 beats / min), dose not expand.
to ease tachycardia induced hypoglycemia. The use of hypoglycemic drug therapy in patients with diabetes also have to be careful when using. Propranolol can be extended hypoglycemic drugs on the role of insulin.
of patients with ischemic heart disease, with the use of other beta blocker, not arbitrary treatment interruption. Can a dose of β antagonist instead of the other, before stopping or gradual reduction in dose. First time available on the same dose of propranolol tablets (40mg each) instead, and then gradually reduce the dose.
patients taking beta blocker like to use preparations containing epinephrine (non-intestinal administration), require careful because, in rare cases, lead to vasoconstriction, hypertension and bradycardia. Le
can switch to the beta blocker, to be careful, if β - adrenergic receptor antagonist and can be used in Guernsey, in the beta-adrenergic receptor antagonist suspended after a few days to be suspended --- (Please also refer to Le manual).
β - adrenergic antagonist and the first-line anti-rhythm disorder drugs (such as topiramate amine C) must be used very carefully. The weaker
ventricular function of patients with beta-adrenergic antagonist Weilamomier also be used to care for patients conduction abnormalities, while not using these drugs, in which a drug suspension shall within 48 hours after intravenous injection of a drug.
anesthesia: For most patients, surgery can be suspended in β - adrenergic receptor antagonist drug is not right, but in the use of ether, cyclopropane and trichloroethane anesthetics like to be very careful. If vagus nerve advantage (va-gaidominance) can be used atropine (1 ~ 2mgiv) to rectify.
pregnancy: As with other drugs, except when necessary, not to take pregnant women, there is no evidence of teratogenicity: Long-term use should be regularly checked blood, blood pressure, cardiac function and liver function.
diabetes should regularly check blood sugar, with a history of allergies, congestive heart failure, diabetes, allergies and bronchitis or emphysema, liver dysfunction, hypothyroidism, Raynaud's syndrome or other peripheral vascular diseases and renal dysfunction, the patient anti.
specifications: 40mg.
Storage: kept sealed.
Validity: tentative three years.
prescription drugs: yes
Warning:The information is only as a reference for new drug researcher and the patients or doctors can't use it as prescription basis!
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