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drug name : propranolol hydrochloride
English : Propranolol Hydrochloride
Alias : k to Entebbe; Chennai metoprolol; propranolol, propranolol
Foreign Name : Propranolol
pharmacological effects : cardiac beta receptor blocker, resulted in bradycardia, reduced myocardial contractility, atrioventricular slow down, reduce cardiac output and reducing myocardial oxygen consumption. High concentrations (10-20 µ g / ml), with the membrane stability, reduce action potential duration and effective refractory period, the lower the self-discipline and curb triggered activity.
indications : for various reasons arising from the room and ventricular arrhythmias, particularly in view of increased circulating catecholamine or catecholamine were higher sensitivity. With cardiac glycosides and use, may slow down the rate of ventricular atrial fibrillation. The adrenaline-dependent long QT syndrome with reverse ventricular tachycardia a good effect.
block the goods have to be sympathetic adrenergic amines or the role of one hand, the heart rate, myocardial contractility weakened, lowering blood pressure, thereby reducing cardiac oxygen consumption is conducive to angina. Other increases due to enhanced ventricular ejection time and ventricular volume increase oxygen consumption, which does not help angina. But both of marketing, and propranolol is still effective drugs to combat angina. The goods and S-inhibitory effect on sperm have. Vaginal delivery after the entry into force of the rapid effect can be maintained 4-10 hours.
consumption usage :
: angina treatment with the dose. If 10 mg / time, three times a day invalid, incremental to 20mg / time, the 1st 3 to 4 times, or even 40 mg / time, the 1st 3 ~ 4. Vagina : Housing in advance to the depths of vaginal tablets Add each one. Intravenous : 2.5 ~ 5 mg glucose dissolved in 20ml, every two to three minutes of the injection of 1 mg slow injection.
adverse reactions :
Visibility dreams, dizziness, depression, hallucinations, drowsiness, headache, drink flu, abnormal feeling, insomnia, anxiety and so on. Long-term use of a large number of serious depression and even suicide attempts. Reduced myocardial contractility, induce or aggravate heart failure, sinus bradycardia, sinus cardioplegia, atrioventricular block. Induce or aggravate bronchial spasm, cold limbs and intermittent claudication. Hypoglycemic agents intensified the hypoglycemic effect, and to conceal from hypoglycemia.
Note :
â‘?with cimetidine, metoclopramide, and use of diuretics, the goods blood concentration increased. â‘?with lidocaine, quinidine, An Ti, and over-used, which can reduce the clearance rate, improve blood concentration. â‘?rifampin used, the goods blood drug concentration lower. â‘?and chlorpromazine, hydralazine, quinidine and use, which can increase the bioavailability. â‘?congestive power failure, sick sinus syndrome, atrioventricular block, chronic obstructive respiratory illness and the change in peripheral vascular disease hanged. â‘?caution pregnant women.
specifications : tablet : 10mg per unit. Using vaginal tablet : 80mg per unit. Injection : 5ml : 5 mg (hydrochloride)
categories :
Warning:The information is only as a reference for new drug researcher and the patients or doctors can't use it as prescription basis!
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