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Molecular formula : C22H17ClN2 MW : 344.84 CAS No. :23593-75-1
nature : the white powder or colorless crystalline powder. 147-149 ° C melting point. Soluble ethanol, acetone, chloroform, almost insoluble in water. Odorless, tasteless, the acid decomposition quickly. Clotrimazole hydrochloride, 159 ° C melting point.
preparation methods : o-benzoic acid by esterification, Addition, hydrolysis, chlorination, generated from condensation. Also be o-chlorotoluene be chlorinated by the o-benzotrichloride, then three aluminum chloride in the presence of benzene and condensation generated two phenyl - (2-chlorophenyl) methyl chloride, the last with imidazole condensation clotrimazole.
purposes : broad-spectrum antifungal. For systemic fungal infections, but also for other local fungal infection.
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